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PD-1/PD-L1-IN-57

PD-1/PD-L1-IN-57 (Compound J29) is a PD-1/PD-L1 inhibitor with an IC50 of 5.5 nM. PD-1/PD-L1-IN-57 has a strong immunoregulatory activity, effectively promotes T-cell proliferation and restores the killing ability of tumor cells. PD-1/PD-L1-IN-57 can be used for tumor immunotherapy research[1].

Product Specifications

UNSPSC

12352005

Target

PD-1/PD-L1

Related Pathways

Immunology/Inflammation

Field of Research

Cancer; Inflammation/Immunology

Smiles

OC[C@H](C(O)=O)NCC1=CC(C(N2CCC3=C2C=CC=C3C4=CC=CC=C4)=O)=NN1C

Molecular Formula

C23H24N4O4

Molecular Weight

420.46

References & Citations

[1]Deng W, et al. Discovery of Pyrazole-Containing 4-Arylindolines as Potent Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction[J]. ACS Medicinal Chemistry Letters, 2025.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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