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Glycosyltransferase-IN-2

Glycosyltransferase-IN-2 (Compound 20) is a Glycosyltransferase inhibitor. Glycosyltransferase-IN-2 has a broad-spectrum anticoronavirus activity with IC50s of 11.3, 5.5 and ~16.2 μM for MHV, HCoV-NL63 and SARS-CoV-2, respectively. Glycosyltransferase-IN-2 interferes with the coronavirus infectivity, alters viral protein glycosylation with inhibition of interaction with the ACE2 receptor or SC-VLP secretion, and inhibits RNA replication. Glycosyltransferase-IN-2 can be used for coronavirus infections research[1].

Product Specifications

UNSPSC

12352005

Target

Angiotensin-converting Enzyme (ACE) ; DNA/RNA Synthesis; Glycosyltransferase; SARS-CoV

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

O=C(C=C1)NC(N1[C@@H]2O[C@H](CN3N=NC(CS[C@H]4[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O4)=C3)[C@@H](O[Si](C)(C(C)(C)C)C)[C@H]2O[Si](C)(C(C)(C)C)C)=O

Molecular Formula

C38H61N5O14SSi2

Molecular Weight

900.15

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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