PROTAC BRD2 BD1 Degrader-1
PROTAC BRD2 BD1 Degrader-1 (compound 21-1) is a potent and selective BRD2 BD1 PROTAC degrader. PROTAC BRD2 BD1 Degrader-1 induces the association of BRD2 BD1 and von Hippel–Lindau-elongin C-elongin B (VCB) . (Pink: BRD2-BD1 Ligand (HY-175679) ; Blue: E3 ligase ligand (HY-125845) ; Black: Linker (HY-W069332) ) [1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Field of Research
Cancer
Smiles
CC1=CC=CC2=C1CCN(C2)C3=NC(N4CCC(CC4)CCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](C[C@H]5C(NCC6=CC=C(C=C6)C7=C(N=CS7)C)=O)O)=O)=O)=NC(N8CCC(C8)C9=NC=CN9C)=N3
Molecular Formula
C51H66N12O4S
Molecular Weight
943.21
References & Citations
[1]Chow YT, et al. Selectivity Profiling of Bromodomain PROTACs Using Chemical Inducers of Proximity DNA-Encoded Library Screening. ACS Chem Biol. 2025 Aug 12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD2
Curated Selection
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