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PROTAC BRD2 BD1 Degrader-1

PROTAC BRD2 BD1 Degrader-1 (compound 21-1) is a potent and selective BRD2 BD1 PROTAC degrader. PROTAC BRD2 BD1 Degrader-1 induces the association of BRD2 BD1 and von Hippel–Lindau-elongin C-elongin B (VCB). (Pink: BRD2-BD1 Ligand ; Blue: E3 ligase ligand (HY-125845) ; Black: Linker (HY-W069332) ).

Product Specifications

UNSPSC

12352005

Target

Epigenetic Reader Domain; PROTACs

Related Pathways

Epigenetics; PROTAC

Field of Research

Cancer

Smiles

CC1=CC=CC2=C1CCN(C2)C3=NC(N4CCC(CC4)CCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](C[C@H]5C(NCC6=CC=C(C=C6)C7=C(N=CS7)C)=O)O)=O)=O)=NC(N8CCC(C8)C9=NC=CN9C)=N3

Molecular Formula

C51H66N12O4S

Molecular Weight

943.21

References & Citations

[1]Chow YT, et al. Selectivity Profiling of Bromodomain PROTACs Using Chemical Inducers of Proximity DNA-Encoded Library Screening. ACS Chem Biol. 2025 Aug 12.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

BRD2

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