THR-β agonist 10

THR-β agonist 10 is an orally active and selective THR-β agonist, with an EC50 of 11 nM. THR-β agonist 10 significantly reduces ALT (Alanine Aminotransferase), TC (Total Cholesterol), and LDL-C (Low-Density Lipoprotein Cholesterol) levels, and improves steatosis, ballooning, inflammation and fibrosis in the metabolic dysfunction-associated steatohepatitis (MASH) mouse model. THR-β agonist 10 can be used for the study of MASH[1].

Product Specifications

UNSPSC

12352100

Target

Thyroid Hormone Receptor

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease; Inflammation/Immunology

Smiles

O=C1NC(N(C2=CC(Cl)=C(N3C=CC4=C3C=CC(N4CC5=CC=C(C#N)C=C5)=O)C(Cl)=C2)N=C1C#N)=O

Molecular Formula

C25H13Cl2N7O3

Molecular Weight

530.32

References & Citations

[1]Liang J, et al. Discovery of Highly Potent, Selective, and Liver-Targeted THR-β Agonists for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis. J Med Chem. 2025 Aug 28;68 (16) :17457-17472.