MRGPRX4 modulator-3
MRGPRX4 modulator-3 (Compound 1C) is a negative allosteric MAS-related G-protein-coupled receptor X4 (MRGPRX4) modulator. MRGPRX4 modulator-3 significantly attenuates Nateglinide (orthosteric agonist) -induced responses with an IC50 of 337 nM. MRGPRX4 modulator-3 can be used for chronic itch (especially cholestatic itch) and pain research[1].
Product Specifications
UNSPSC
12352100
Target
Mas-related G-protein-coupled Receptor (MRGPR)
Related Pathways
GPCR/G Protein
Field of Research
Neurological Disease
Smiles
C[C@]1(C2(C)C)/C(C[C@@H]2CC1)=N\NC3=NC(C4=CC=C(F)C=C4)=CS3
Molecular Formula
C19H22FN3S
Molecular Weight
343.46
References & Citations
[1]Haider S, et al. Terpene-Based Thiazole Hydrazines as Negative Allosteric Modulators of MRGPRX4: In Vitro Evaluation and Binding Site Analysis[J]. ACS Medicinal Chemistry Letters, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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