GABAA receptor modulator-10
GABAA receptor modulator-10 is an orally active, potent positive allosteric modulator (PAM) of the α1β2γ2 GABAA receptor with favorable blood-brain barrier (BBB) penetration. GABAA receptor modulator-10 enhances α1β2γ2 GABAA receptor function and potentiates GABA-evoked currents. GABAA receptor modulator-10 demonstrates potent antiepileptic efficacy in both the Pentetrazol (PTZ) - and Kainic Acid (KA) (HY-N2309) -induced mice epilepsy models. GABAA receptor modulator-10 can be used for the study of epilepsy[1].
Product Specifications
UNSPSC
12352100
Target
GABA Receptor
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(NC1=CC=C(Cl)C=C1)C2=CC(C3=C4N=CN(CC)C4=NC=N3)=CC=C2F
Molecular Formula
C20H15ClFN5O
Molecular Weight
395.82
References & Citations
[1]Gao Y, et al. Discovery of Novel Antiepileptic Agents Targeting the α1β2γ2 GABAA Receptor. J Med Chem. 2025 Aug 28;68 (16) :17971-17989.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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