IDOR-1104-0086
IDOR-1104-0086 is an orally active Kv7 potassium channel opener with an EC50 of 210 nM that can cross blood-brain barrier. IDOR-1104-0086 displays strong selectivity against the hERG channel with an IC20 of 25 μM. IDOR-1104-0086 exhibits efficacy in two rodent models of epilepsy and a favorable tolerability profile. IDOR-1104-0086 can used for the study of epilepsy[1].
Product Specifications
CAS Number
[2756581-81-2]
UNSPSC
12352100
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Purity
98.98
Smiles
O=C(NCC1=CC=CC(C(F)(F)F)=C1)NC2(C3)CC3(C(F)F)C2
Molecular Formula
C15H15F5N2O
Molecular Weight
334.28
References & Citations
[1]Siegrist R, et al. Discovery and In-Vivo Characterization of Kv7 Channel Openers through a Phenotypic Approach. J Med Chem. 2025 Aug 28;68 (16) :17412-17426.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Voltage-gated potassium channel
Available Sizes
Curated Selection
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