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NNRT-IN-12

NNRT-IN-12 (compound 19) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor with an IC50 value of 0.107 μM for WT HIV-1 RT. NNRT-IN-12 shows anti-HIV-1 activity with EC50 value of 14.1, 5.03, 7.64, 27.1 nM for L100I, K103N, Y181C, Y188L mutant HIV-1 strains, respectively. NNRT-IN-12 shows cytotoxicity[1].

Product Specifications

UNSPSC

12352100

Target

HIV; Reverse Transcriptase

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(N)C1=CC=C(CN2CC(F)(F)C(NC3=NC(OC4=C(C)C=C(/C=C/C#N)C=C4C)=C5C(C=CS5)=N3)CC2)C=C1

Molecular Formula

C30H28F2N6O2S

Molecular Weight

574.64

References & Citations

[1]Zhou Z, et al. Structure-Based Drug Design Yields Diarylpyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. ACS Infect Dis. 2025 Aug 6.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HIV-1

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