TGF-β/Smad-IN-2
TGF-β/Smad-IN-2 is an orally active TGF-β/Smad inhibitor. TGF-β/Smad-IN-2 inhibits TGF-β-induced fibroblast-to-myofibroblast differentiation and collagen deposition, with an IC50 value of 102 μM for collagen reduction in LL29 cells. TGF-β/Smad-IN-2 exerts its effects through modulation of the SMAD3/SMAD7 signaling pathway. TGF-β/Smad-IN-2 reduces lung index in pulmonary fibrosis mice. TGF-β/Smad-IN-2 can be used for the study of pulmonary fibrosis[1].
Product Specifications
UNSPSC
12352100
Target
TGF-beta/Smad
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Inflammation/Immunology
Smiles
O=C1C(CN2CCOCC2)=CC(C)=CN1C3=CC=CC=C3
Molecular Formula
C17H20N2O2
Molecular Weight
284.35
References & Citations
[1]Laxman D. Nandawadekar, et al.Design and Synthesis of Novel Pirfenidone Analogues for Targeting Fibroblast Differentiation via Transforming Growth Factor-β/Smad Pathway Using In Vitro and In Vivo Models.ACS Pharmacol. Transl. Sci. 2025
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
