AChE/BChE-IN-29
AChE/BChE-IN-29 is an AChE/BChE inhibitor. AChE/BChE-IN-29 exhibits balanced dual cholinesterase inhibitory activity with IC50 values of 2.1 μM for Electrophorus electricus AChE (eeAChE) and 6.3 μM for equine serum butyrylcholinesterase (eqBChE) . AChE/BChE-IN-29 effectively inhibits amyloid-β (Aβ42) aggregation and tau protein aggregation in E. coli cell models. AChE/BChE-IN-29 can be used for the study of Alzheimer’s disease (AD) [1].
Product Specifications
UNSPSC
12352100
Target
Amyloid-β; Cholinesterase (ChE) ; Tau Protein
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C1C2=C(OC3=C1C=CC(OC)=C3)C=C4C(COC5=C4C=C(Cl)C=C5)=C2
Molecular Formula
C21H13ClO4
Molecular Weight
364.78
References & Citations
[1]Daniela Malafaia, et al. Design, Synthesis and Biological Evaluation of Chromeno[3,4-b]xanthones as Multifunctional Agents for Alzheimer’s Disease. ACS Chem. Neurosci. 2025, 16, 16, 3184–3203
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE
Curated Selection
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