NLRP3/URAT1-IN-1
NLRP3/URAT1-IN-1 is an orally active double inhibitor of NLRP3 and URAT1 (IC50 = 3.81 μM) . NLRP3/URAT1-IN-1 inhibits IL-1β release in LPS (HY-D1056) and ATP-stimulated mouse bone marrow-derived macrophages (BMDMs), with an IC50 of 2.61 μM. NLRP3/URAT1-IN-1 reduces serum uric acid (SUA) and alleviates liver/kidney damage in mice with acute hyperuricemia (HUA) . NLRP3/URAT1-IN-1can be used for the study of gout and hyperuricemia[1].
Product Specifications
CAS Number
[2994637-53-3]
UNSPSC
12352100
Target
GLUT; Interleukin Related; NOD-like Receptor (NLR) ; OAT; URAT1
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Inflammation/Immunology; Metabolic Disease
Smiles
O=C(C(N1CC2=C3C=CC=CC3=C(Br)C=C2)=CC4=C1C=CC=C4)NS(=O)(C5=CC=CS5)=O
Molecular Formula
C24H17BrN2O3S2
Molecular Weight
525.44
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; NLRP3
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