Troponin-IN-1

Troponin-IN-1 is a troponin inhibitor. Troponin-IN-1 protects OGD/R-injured H9c2 cardiomyocytes by reducing LDH leakage, pyroptosis and ROS accumulation. Troponin-IN-1 inhibits NO production and IL-1β/TNF-α/IL-18 release in LPS (HY-D1056) -induced RAW264.7 cells. Troponin-IN-1 acts via caspase-1/GSDMD/IL-18 pathway. Troponin-IN-1 reduces myocardial infarct size in LAD-induced myocardial ischemia/reperfusion (MI/R) male rats. Troponin-IN-1 can be used for the study of myocardial ischemia/reperfusion (MI/R) injury[1].

Product Specifications

UNSPSC

12352100

Target

Caspase; Interleukin Related; Pyroptosis; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cardiovascular Disease

Smiles

O=C(O[C@@H]1[C@](C2(C)C)(C)CC[C@@H]2C1)/C=C/C3=CC=C(OC)C(OC)=C3OC

Molecular Formula

C22H30O5

Molecular Weight

374.47

References & Citations

[1]Gu Y, et al. Novel chiral borneol derivatives as potential cardioprotective agents: Design, synthesis and biological evaluation. Bioorg Chem. 2025 Aug;163:108767.