COX-2-IN-57
COX-2-IN-57 is an orally active COX-2 inhibitor with an IC50 value of 0.02 μM. COX-2-IN-57 reduces MyD88 expression and decreases serum levels of COX-2, PGE2, and COX-1 in Cisplatin /radiation-induced neuropathy rat model. COX-2-IN-57 demonstrates superior antinociceptive efficacy in hot plate, cold allodynia, and Randall-Selitto tests, along with hepato-/renal protection. COX-2-IN-57 can be used for the study of inflammation[1].
Product Specifications
UNSPSC
12352100
Target
COX; MyD88
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(O)CC1=CC=CC=C1N(C2=C(Cl)C=CC=C2Cl)C(CSC(N3C4=CC=CC=C4)=NC5=C(C=C6C(C=CC=C6)=C5)C3=O)=O
Molecular Formula
C34H23Cl2N3O4S
Molecular Weight
640.54
References & Citations
[1]Ghorab MM, et al. Design and synthesis of novel diclofenac-based quinazoline derivatives enhancing cisplatin and radiation impacts via MyD88 and COX-2/PGE2 modulation. Eur J Med Chem. 2025 Nov 15;298:117997.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2
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