EGFR/VEGFR2-IN-6

EGFR/VEGFR2-IN-6 (Compound 3k) is a dual-functional inhibitor of EGFR and VEGFR2 with IC50s of 10.53 and 3.37 μM for EGFR and VEGFR2, respectively. EGFR/VEGFR2-IN-6 has significant anti-proliferation activity against breast cancer cells, and induces G0/G1 cell cycle arrest and cell apoptosis, especially early apoptosis. EGFR/VEGFR2-IN-6 can be used for cancers research[1].

Product Specifications

UNSPSC

12352100

Target

EGFR; VEGFR

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

FC(C1=CC=C(N/N=C/C2=C(OC(C3=CC(OC)=CC(OC)=C3)=C4)C4=CC([N+]([O-])=O)=C2)C=C1)(F)F

Molecular Formula

C24H18F3N3O5

Molecular Weight

485.41

References & Citations

[1]Nkoana JK, et al. Examining the 2-aryl-5-nitrobenzofuran-based hydrazones for anti-breast (MCF-7) cancer activity, potential to induce cell cycle arrest and inhibit receptor tyrosine kinases (VEGFR-2 & EGFR) . Eur J Med Chem. 2025 Nov 15;298:118018.