ALOX5 stabilizer-1
ALOX5 stabilizer-1 is an arachidonate 5-lipoxygenase (ALOX5) stabilizer with a Kd of 7.26 μM. ALOX5 stabilizer-1 inhibits β-catenin protein levels and then suppresses STAT3 signal pathway. ALOX5 stabilizer-1 induces lung cancer cells apoptosis, inhibited cell migration and proliferation. ALOX5 stabilizer-1 can used for the study of non-small cell lung cancer (NSCLC) [1].
Product Specifications
UNSPSC
12352100
Target
Apoptosis; Lipoxygenase; STAT; β-catenin
Related Pathways
Apoptosis; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt
Field of Research
Cancer
Smiles
C=C1C(O[C@H]2[C@H]1CC/C(CN3C=C(N=N3)COC4=CC=C(C=C4)C(/C=C/C5=CC=CN=C5)=O)=C\CC[C@]6(O[C@@H]26)C)=O
Molecular Formula
C32H32N4O5
Molecular Weight
552.62
References & Citations
[1]Bai Y, et al. Design, synthesis and bioactivity evaluation of parthenolide-chalcone hybrids as potential anti-lung cancer agents. Bioorg Chem. 2025 Jul 26;164:108808.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3
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