ALOX5 stabilizer-1

ALOX5 stabilizer-1 is an arachidonate 5-lipoxygenase (ALOX5) stabilizer with a Kd of 7.26 μM. ALOX5 stabilizer-1 inhibits β-catenin protein levels and then suppresses STAT3 signal pathway. ALOX5 stabilizer-1 induces lung cancer cells apoptosis, inhibited cell migration and proliferation. ALOX5 stabilizer-1 can used for the study of non-small cell lung cancer (NSCLC) [1].

Product Specifications

UNSPSC

12352100

Target

Apoptosis; Lipoxygenase; STAT; β-catenin

Related Pathways

Apoptosis; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt

Field of Research

Cancer

Smiles

C=C1C(O[C@H]2[C@H]1CC/C(CN3C=C(N=N3)COC4=CC=C(C=C4)C(/C=C/C5=CC=CN=C5)=O)=C\CC[C@]6(O[C@@H]26)C)=O

Molecular Formula

C32H32N4O5

Molecular Weight

552.62

References & Citations

[1]Bai Y, et al. Design, synthesis and bioactivity evaluation of parthenolide-chalcone hybrids as potential anti-lung cancer agents. Bioorg Chem. 2025 Jul 26;164:108808.