RSL3-NH2

RSL3-NH2 is a GPX4 inhibitor and Ferroptosis inducer. RSL3-NH2 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

[3051815-39-2]

UNSPSC

12352100

Target

ADC Payload; Ferroptosis; Glutathione Peroxidase

Related Pathways

Antibody-drug Conjugate/ADC Related; Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

NC(C=C1)=CC=C1[C@H](N2C(CCl)=O)C(NC3=C4C=CC=C3)=C4C[C@@H]2C(OC)=O

Molecular Formula

C21H20ClN3O3

Molecular Weight

397.85

References & Citations

[1]Zhang Y, et al. Development of a bispecific CDH17-GUCY2C ADC bearing the ferroptosis inducer RSL3 for the treatment of colorectal cancer. Cell Death Discov. 2025 Jul 28;11 (1) :347.