RSL3-NH2-Ala-Val-DBCO-PEG4-Maleimide
RSL3-NH2-Ala-Val-DBCO-PEG4-Maleimide is a drug-linker conjugate for ADC. RSL3-NH2-Ala-Val-DBCO-PEG4-Maleimide consists of a GPX4 inhibitor and ferroptosis inducer (RSL3-NH2) and a linker (H-Ala-Val-OH) (HY-P4955). RSL3-NH2-Ala-Val-DBCO-PEG4-Maleimide can be used for synthesis of ADCs[1].
Product Specifications
UNSPSC
12352100
Target
Drug-Linker Conjugates for ADC; Ferroptosis; Glutathione Peroxidase
Related Pathways
Antibody-drug Conjugate/ADC Related; Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(N[C@H](C(N[C@H](C(NC1=CC=C([C@H]2C(NC3=CC=CC=C34)=C4C[C@@H](N2C(CCl)=O)C(OC)=O)C=C1)=O)C)=O)C(C)C)CCCN5N=NC6=C5C7=CC=CC=C7CN(C8=CC=CC=C86)C(CCNC(CCOCCOCCOCCOCCNC(CCN9C(C=CC9=O)=O)=O)=O)=O
Molecular Formula
C69H81ClN12O15
Molecular Weight
1353.91
References & Citations
[1]Nguyen KA, et al. The first ADC bearing the ferroptosis inducer RSL3 as a payload with conservation of the fragile electrophilic warhead. Eur J Med Chem. 2022 Dec 15;244:114863.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4
Frequently Asked Questions
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