RSL3-NH2-Ala-Val-DBCO-PEG4-Maleimide

RSL3-NH2-Ala-Val-DBCO-PEG4-Maleimide is a drug-linker conjugate for ADC. RSL3-NH2-Ala-Val-DBCO-PEG4-Maleimide consists of a GPX4 inhibitor and ferroptosis inducer (RSL3-NH2) (HY-175615) and a linker (H-Ala-Val-OH) (HY-P4955) . RSL3-NH2-Ala-Val-DBCO-PEG4-Maleimide can be used for synthesis of ADCs[1].

Product Specifications

UNSPSC

12352100

Target

Drug-Linker Conjugates for ADC; Ferroptosis; Glutathione Peroxidase

Related Pathways

Antibody-drug Conjugate/ADC Related; Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(N[C@H](C(N[C@H](C(NC1=CC=C([C@H]2C(NC3=CC=CC=C34)=C4C[C@@H](N2C(CCl)=O)C(OC)=O)C=C1)=O)C)=O)C(C)C)CCCN5N=NC6=C5C7=CC=CC=C7CN(C8=CC=CC=C86)C(CCNC(CCOCCOCCOCCOCCNC(CCN9C(C=CC9=O)=O)=O)=O)=O

Molecular Formula

C69H81ClN12O15

Molecular Weight

1353.91

References & Citations

[1]Nguyen KA, et al. The first ADC bearing the ferroptosis inducer RSL3 as a payload with conservation of the fragile electrophilic warhead. Eur J Med Chem. 2022 Dec 15;244:114863.