FLT3/JAK2/BRD4 ligand-1

FLT3/JAK2/BRD4 ligand-1 is a FLT3/JAK2/BRD4 ligand. FLT3/JAK2/BRD4 ligand-1 can be used for synthesis PROTAC FLT3/JAK2/BRD4 Degrader-1 (HY-175610) [1].

Product Specifications

CAS Number

[3067695-60-4]

UNSPSC

12352100

Target

Epigenetic Reader Domain; FLT3; JAK; Ligands for Target Protein for PROTAC

Related Pathways

Epigenetics; JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CC1=C(N=C(N=C1)NC2=CC=C(C(F)=C2)N3CCNCC3)NC4=CC=CC(NS(C(C)(C)C)(=O)=O)=C4

Molecular Formula

C25H32FN7O2S

Molecular Weight

513.63

References & Citations

[1]Xiang Q, et al. Discovery of Potent Dual PROTAC Degraders Targeting BET-Kinase To Overcome FLT3 Inhibitor Resistance. J Med Chem. 2025 Aug 28;68 (16) :17303-17322.