EGFR-IN-171
EGFR-IN-171 is an EGFR inhibitor with an IC50 value of 0.19 μM. EGFR-IN-171 also inhibits vascular endothelial growth factor 2 (VEGFR-2) with an IC50 value of 31.65 μM. EGFR-IN-171 can induce apoptosis and G2/M phase cell cycle arrest. EGFR-IN-171 can be used for cancer research, such as liver and breast cancer[1].
Product Specifications
UNSPSC
12352100
Target
Apoptosis; Bcl-2 Family; EGFR; MDM-2/p53
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1N(C2=CC=CC=C2)C(SC3=COC(C)=C3C4CC(C5=CC=CO5)NC6=CC=CC=C6N4)=NC7=C1C=CC=C7
Molecular Formula
C32H26N4O3S
Molecular Weight
546.64
References & Citations
[1]Soliman SM, et al. Design, antiproliferative potency, and in silico studies of novel 5-methylfuran-3-yl) thio) -3-phenylquinazolin-4 (3H) -one based derivatives as potential EGFR inhibitors. Sci Rep. 2025 Jul 31;15 (1) :27992.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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