MI-2-80
MI-2-80 is a molecular glue degrader. MI-2-80 induces proteins (such as IKZF1/3 and CSNK1A1) to bind to CRBN, promoting their ubiquitination and degradation[1].
Product Specifications
CAS Number
1010099-35-0
UNSPSC
12352100
Target
Casein Kinase; IKZF Family; Molecular Glues
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C1CCC(C(N1)=O)N2C(C3=C(C2=O)C=C(C=C3)NCC4=CC=CC=C4)=O
Molecular Formula
C20H17N3O4
Molecular Weight
363.37
References & Citations
[1]Baek K, et al. Unveiling the hidden interactome of CRBN molecular glues. Nat Commun. 2025 Jul 24;16 (1) :6831.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKZF1; IKZF3
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS7151265 Inquire
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) At4g19890 Polyclonal Antibody
Sign In for Pricing
View Details 
JH88705 1 Each
2,4-Dichloro-5,6-dihydro-6- (phenylmethyl) -7H-pyrrolo[3,4-d]pyrimidin-7-one
Sign In for Pricing
View Details