MI-2-80

MI-2-80 is a molecular glue degrader. MI-2-80 induces proteins (such as IKZF1/3 and CSNK1A1) to bind to CRBN, promoting their ubiquitination and degradation[1].

Product Specifications

CAS Number

[1010099-35-0]

UNSPSC

12352100

Target

Casein Kinase; IKZF Family; Molecular Glues

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC; Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C1CCC(C(N1)=O)N2C(C3=C(C2=O)C=C(C=C3)NCC4=CC=CC=C4)=O

Molecular Formula

C20H17N3O4

Molecular Weight

363.37

References & Citations

[1]Baek K, et al. Unveiling the hidden interactome of CRBN molecular glues. Nat Commun. 2025 Jul 24;16 (1) :6831.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IKZF1; IKZF3

Curated Selection

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