MI-2-80
MI-2-80 is a molecular glue degrader. MI-2-80 induces proteins (such as IKZF1/3 and CSNK1A1) to bind to CRBN, promoting their ubiquitination and degradation[1].
Product Specifications
CAS Number
[1010099-35-0]
UNSPSC
12352100
Target
Casein Kinase; IKZF Family; Molecular Glues
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C1CCC(C(N1)=O)N2C(C3=C(C2=O)C=C(C=C3)NCC4=CC=CC=C4)=O
Molecular Formula
C20H17N3O4
Molecular Weight
363.37
References & Citations
[1]Baek K, et al. Unveiling the hidden interactome of CRBN molecular glues. Nat Commun. 2025 Jul 24;16 (1) :6831.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-175600/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKZF1; IKZF3
Curated Selection
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