Z6466608628

Z6466608628 is a selective PPIL4 molecular glue degrader with an EC50 of 0.34 μM. PPIL4 is a regulator of the BACR spliceosome and it is essential for brain angiogenesis. Z6466608628 can be used for intracranial aneurysm (IA) research[1][2].

Product Specifications

CAS Number

[2869183-63-9]

UNSPSC

12352100

Target

Molecular Glues

Related Pathways

PROTAC

Field of Research

Cancer; Cardiovascular Disease

Smiles

O=C1CCC(C(N1)=O)N2CC3=C(C2=O)C=CC=C3C4=CC=C(C=C4)N5CCNCC5

Molecular Formula

C23H24N4O3

Molecular Weight

404.46

References & Citations

[1]Baek K, et al. Unveiling the hidden interactome of CRBN molecular glues. Nat Commun. 2025 Jul 24;16 (1) :6831. |[2]Barak T, et al. PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans. Nat Med. 2021 Dec;27 (12) :2165-2175.