ACP1-01

ACP1-01 is a bacterial ClpP activator with EC50s of 3.4 and 2.6 μM for Neisseria meningitides ClpP (NmClpP) and Escherichia coli ClpP (EcClpP) . ACP1-01 noncovalently binds to ClpP C sites and activates the protease. ACP1-01 has antibacterial activity. ACP1-01 can be used for bacterial infections research[1][2].

Product Specifications

CAS Number

[1382489-31-7]

UNSPSC

12352100

Target

Bacterial; ClpP

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

CC(C(NCCSC1=CC=CC=C1C(F)(F)F)=O)(S(=O)(C2=NC=C(C=C2)C(F)(F)F)=O)C

Molecular Formula

C19H18F6N2O3S2

Molecular Weight

500.48

References & Citations

[1]Barghash MM, et al. Small molecule dysregulation of ClpP activity via bidirectional allosteric pathways. Structure. 2025 Aug 5:S0969-2126 (25) 00261-8. |[2]Mabanglo MF, et al. ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores. Commun Biol. 2019 Nov 13;2:410.