ADEP-14
ADEP-14 is a bacterial ClpP activator with EC50s of 0.46 and 3.67 μM for Neisseria meningitides ClpP (NmClpP) and Escherichia coli ClpP (EcClpP) . ADEP-14 binds to ClpP H sites and activates the protease. ADEP-14 has antibacterial activity. ADEP-14 can be used for bacterial infections research[1].
Product Specifications
CAS Number
[1846579-07-4]
UNSPSC
12352100
Target
ClpP
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
[H][C@@]12C[C@H](CN1C([C@@H](NC([C@@]3(CCCCN3C([C@@]4(CCCN4C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/C=C/CCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)[H])=O)C)=O)C
Molecular Formula
C41H54F2N6O8
Molecular Weight
796.90
References & Citations
[1]Barghash MM, et al. Small molecule dysregulation of ClpP activity via bidirectional allosteric pathways. Structure. 2025 Aug 5:S0969-2126 (25) 00261-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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