HEAL-116
HEAL-116 is a potent, specific and orally active 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) inhibitor with an IC50 of 1.18 μM and a KD of 1.32 μM. HEAL-116 inhibits DHEA (HY-14650) metabolism and DHEA-induced target gene expression and cell proliferation. HEAL-116 can be used for cancer research, such as prostate cancer[1].
Product Specifications
CAS Number
[3059767-85-7]
UNSPSC
12352100
Target
3β-HSD
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
OC1=CC(OC=C(C2=CC=C(Cl)C(CN3CCOCC3)=C2)C4=O)=C4C=C1
Molecular Formula
C20H18ClNO4
Molecular Weight
371.81
References & Citations
[1]He D, et al. Fine structural design of 3βHSD1 inhibitors for prostate cancer therapy. Proc Natl Acad Sci U S A. 2025 Jul;122 (26) :e2422267122.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
3β-HSD I
Available Sizes
Curated Selection
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