Photosensitizer-7

Photosensitizer-7 is a endoplasmic reticulum (ER) -targeted photosensitizer (PS) (λab = 610 nm, λem = 622 nm) . Photosensitizer-7shows an IC50 of 4.006 μM in HeLa cells and 3.28 μM in MCF-7 cells under light irradiation. Photosensitizer-7 exhibits dose-dependent cellular uptake and predominant colocalization with ER. Photosensitizer-7 induces dose-dependent intracellular ROS generation, reduces mitochondrial membrane potential, and increases apoptosis upon light irradiation in cells. Photosensitizer-7 significantly inhibits tumor growth in MCF-7 tumor-bearing mice. Photosensitizer-7 can be used for the study of photodynamic anticancer applications[1].

Product Specifications

UNSPSC

12352100

Target

Apoptosis; Photosensitizer; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

FB1(F)[N]2=C(c3c(C)cc(OCC)cc3C)C(C=CC=C4)=C4C2=C(c5cc(F)c(F)cc5)C6=C7C=CC=CC7=C(c8c(C)cc(OCC)cc8C)N16

Molecular Formula

C43H37BF4N2O2

Molecular Weight

700.57

References & Citations

[1]Zhang F, et al. Facile synthesis and biological evaluation of [a]-benzannulated BODIPY derivatives as novel heavy-atom-free photosensitizers for photodynamic anticancer therapy. Bioorg Chem. 2025 Aug;163:108766.