DPP-4-IN-17

DPP-4-IN-17 is an orally active and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with an IC50 value of 0.12 nM. DPP-4-IN-17 increases the enzyme's Km value (75.73 μM vs. 27.18 μM of substrate alone) and reduces catalytic efficiency. DPP-4-IN-17 reduces blood glucose levels and reverses weight loss in Streptozotocin (STZ) (HY-13753) /Nicotinamide (NA) (HY-B0150) -induced diabetic rats. DPP-4-IN-17 can be used for the study of type 2 diabetes mellitus (T2DM) [1].

Product Specifications

UNSPSC

12352100

Target

Dipeptidyl Peptidase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

COC([C@@H]1CCCN1C([C@@H](NC([C@@H]2CCCN2C(OC(C)(C)C)=O)=O)CCCCNC([C@@H]3CCCN3C(OC(C)(C)C)=O)=O)=O)=O

Molecular Formula

C32H53N5O9

Molecular Weight

651.79

References & Citations

[1]Jaglan S, et al. Rationally designed small peptides targeting DPP-4: Identification of potent anti-diabetic agents. Bioorg Chem. 2025 Aug;163:108781.