XSJ81
XSJ81 is an orally active anti-cancer agent. XSJ81 significantly inhibits the proliferation of ampullary carcinoma (AC) DPC-X3 cells with an IC50 of 0.655 μM. XSJ81 inhibits the colony formation, arrests cell cycle at the G2/M phase and inhibits the migration in DPC-X3 cells. XSJ81 induces DNA damage and apoptosis in DPC-X3 cells. XSJ81 demonstrates significant anti-tumor efficacy in mice bearing DPC-X3 xenografts. XSJ81 can be used for the study of ampullary carcinoma[1].
Product Specifications
UNSPSC
12352100
Target
Apoptosis; Bcl-2 Family; Topoisomerase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC[C@]1(C(OC=C2C(N3CC4=CC5=CC=CC=C5N=C4C3CC21)=O)=O)OC(CNC(NS(=O)(C6=CC=C(C=C6)C)=O)=O)=O
Molecular Formula
C30H28N4O8S
Molecular Weight
604.63
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I
Frequently Asked Questions
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