EGFR-IN-170

EGFR-IN-170 (Compound 5c) is an EGFR inhibitor with an IC50 of 5.17 μM. EGFR-IN-170 induces apoptosis by inhibiting Bcl2 expression and activating Bax expression with a significantly increased ratio of Bax/Bcl2. EGFR-IN-170 has potent anticancer activity and inhibits the cell growth of resistant lung cancer cells[1].

Product Specifications

UNSPSC

12352100

Target

Apoptosis; Bcl-2 Family; EGFR

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

CC(OC[C@H]1O[C@@H]([C@H]([C@H]([C@@H]1OC(C)=O)OC(C)=O)OC(C)=O)N2C=C(N=N2)COC3=CC(C4=CC=CC=C4C3=O)=O)=O

Molecular Formula

C27H27N3O12

Molecular Weight

585.52

References & Citations

[1]Singh K, et al. Design, synthesis, and molecular docking of 1,4-naphthoquinone based glycoconjugates as chiral glycohybrids targeting lung cancer. Bioorg Chem. 2025 Aug;163:108776.