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Calcium N5-methyltetrahydrofolate

Calcium N5-methyltetrahydrofolate (NSC173328) is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. IC50 value: Target:

Product Specifications

CAS Number

26560-38-3

Product Name Alternative

NSC173328; 5-Methyl THF (calcium)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antifolate

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Purity

99.85

Solubility

H2O : 18.18 mg/mL (ultrasonic; warming; adjust pH to 2 with 1 M HCL; heat to 60°C)

Smiles

O=C([O-])CC[C@@H](C([O-])=O)NC(C1=CC=C(NCC2N(C)C3=C(N=C(N)NC3=O)NC2)C=C1)=O.[Ca+2]

Molecular Formula

C20H23CaN7O6

Molecular Weight

497.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Levomefolic acid. From Wikipedia, the free encyclopedia

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Int J Pharm. 2019 Feb 10:556:89-96.|Appl Microbiol Biotechnol. 2024 Dec;108 (1) :1-15.|Aquac Rep. 2025 Apr 15.|bioRxiv. 2025 Nov 20.|J Pharm Biomed Anal. 2025 Oct 3:268:117178.|J Pharm Pharmacol. 2019 Nov;71 (11) :1645-1654.|J Transl Med. 2023 Jun 6;21 (1) :365.|Nucleic Acids Res. 2023 Jan 25;51 (2) :952-965.

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