Tubulin/VEGFR-2-IN-1
Tubulin/VEGFR-2-IN-1 is a dual inhibitor of tubulin and VEGFR-2 (IC50 = 1.52 μM) with anti-angiogenic activity. Tubulin/VEGFR-2-IN-1 exhibits potent cytotoxicity against the cancer cells. Tubulin/VEGFR-2-IN-1 elevates ROS production, induces apoptosis and causes G0/G1 phase arrest in HepG-2 cells. Tubulin/VEGFR-2-IN-1 inhibits the migratory ability and the clonogenic ability in HepG-2 cells. Tubulin/VEGFR-2-IN-1 can be used for the study of cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin; Reactive Oxygen Species (ROS) ; VEGFR
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C([C@]12[C@H](C(N3CCN(CC4=CC=CC=C4)CC3)=O)[C@H]1C5=CC=C(OC)C=C5)NC6=C2C=C(Br)C=C6
Molecular Formula
C29H28BrN3O3
Molecular Weight
546.45
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
Frequently Asked Questions
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