Tubulin/VEGFR-2-IN-1

Tubulin/VEGFR-2-IN-1 is a dual inhibitor of tubulin and VEGFR-2 (IC50 = 1.52 μM) with anti-angiogenic activity. Tubulin/VEGFR-2-IN-1 exhibits potent cytotoxicity against the cancer cells. Tubulin/VEGFR-2-IN-1 elevates ROS production, induces apoptosis and causes G0/G1 phase arrest in HepG-2 cells. Tubulin/VEGFR-2-IN-1 inhibits the migratory ability and the clonogenic ability in HepG-2 cells. Tubulin/VEGFR-2-IN-1 can be used for the study of cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin; Reactive Oxygen Species (ROS) ; VEGFR

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C([C@]12[C@H](C(N3CCN(CC4=CC=CC=C4)CC3)=O)[C@H]1C5=CC=C(OC)C=C5)NC6=C2C=C(Br)C=C6

Molecular Formula

C29H28BrN3O3

Molecular Weight

546.45

References & Citations

[1]Dastari S, et al. Design, synthesis and biological evaluation of spirocyclopropyl oxindole-piperazine/morpholine-based carboxamides as potential anticancer agents. Bioorg Chem. 2025 Aug;163:108784.