SOS1-IN-22

SOS1-IN-22 is a son of sevenless homolog 1 (SOS1) inhibitor. SOS1-IN-22 can inhibit KRAS-G12C/SOS1 complex formation with an IC50 value of 40.28 nM. SOS1-IN-22 can reduce phosphorylation ERK levels. SOS1-IN-22 can be used for the research of cancer, such as pancreatic carcinoma and appendiceal carcinoma[1].

Product Specifications

CAS Number

[3092445-74-1]

UNSPSC

12352005

Target

PERK; SOS1

Related Pathways

Cell Cycle/DNA Damage; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C1C(C)(C)C2=NC(C)=NC(N[C@H](C)C3=CC=CC(C(F)F)=C3F)=C2CN1C4CCOCC4

Molecular Formula

C24H29F3N4O2

Molecular Weight

462.51

References & Citations

[1]Chen X, et al. Development and biological evaluation of novel SOS1 inhibitors featuring 5,8-dihydropyrido[4,3-d]pyrimidin-7 (6H) -one scaffold. Bioorg Med Chem Lett. 2025 Dec 1;128:130344.