MMP-9-IN-12
MMP-9-IN-12 is a matrix metalloproteinase-9 (MMP-9) inhibitor with an IC50 of 6.57 μM. MMP-9-IN-12 shows an IC50 value of 1.54 μM for HCT-116 cells. MMP-9-IN-12 induces cell apoptosis, ROS production and mitochondrial depolarization. MMP-9-IN-12 inhibits cells migration and disrupts cell cycle progression. MMP-9-IN-12 can be used for the research of colorectal cancer (CRC) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; MMP; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COC1=C(OCC2=NN=C(C3=CC=CC=C3Cl)O2)C(C4)=C(C=C1)CC5N4CCC6=CC7=C(OCO7)C=C56
Molecular Formula
C28H24ClN3O5
Molecular Weight
517.96
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-9
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