Tubulin-IN-54

Tubulin-IN-54 is a tubulin inhibitor. Tubulin-IN-54 exhibits anti-proliferative activity against various cancer cells. Tubulin-IN-54 inhibits tubulin polymerization, disrupts microtubule networks, induces G2/M cell cycle arrest, and promotes cancer cell apoptosis. Tubulin-IN-54 demonstrates significant anti-tumor efficacy in mice bearing PC-3/TxR xenografts. Tubulin-IN-54 can be used for the study of taxane-resistant cancers (prostate cancer, melanoma) [1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(C1=CC(OC)=C(C(OC)=C1)OC)C2=NC(C3=CC=CC4=C3C=CN4)=CN2

Molecular Formula

C21H19N3O4

Molecular Weight

377.39

References & Citations

[1]Albadari N, et al. Design and synthesis of novel 4-aryl-2-benzoyl-imidazoles as colchicine binding site inhibitors. Eur J Med Chem. 2025 Nov 15;298:118021.