VEGFR-2-IN-72
VEGFR-2-IN-72 is a selective VEGFR-2 inhibitor with an IC50 of 22.2 nM. VEGFR-2-IN-72 exhibits anticancer activity against HepG2 and Hep3B human HCC cell lines with IC50s of 15.7 and 2.4 μM. VEGFR-2-IN-72 can cause a mild blockage of the cell cycle and induce cell aopoptosis. VEGFR-2-IN-72 can used for the study of hepatocellular carcinoma (HCC) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; VEGFR
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(C1=C(OC)C=C2N=CC=C(OC3=CC(C4=CC=CC(C(C)C)=C4)=C(NC(NC5CC5)=O)C=C3)C2=C1)N
Molecular Formula
C30H30N4O4
Molecular Weight
510.58
References & Citations
[1]Sun L, et al. Design, synthesis, and anti-hepatocellular carcinoma activity evaluation of aryl Lenvatinib derivatives: Exploring potential VEGFR-2 inhibitors. Bioorg Chem. 2025 Jul 26;164:108799.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
GTR15388755 1 Vial
Lentiviral human TCEA1 sgRNA gene knockout kit - Lentiviral human TCEA1 sgRNA gene knockout kit (25)
Sign In for Pricing
View Details 