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VEGFR-2-IN-72

VEGFR-2-IN-72 is a selective VEGFR-2 inhibitor with an IC50 of 22.2 nM. VEGFR-2-IN-72 exhibits anticancer activity against HepG2 and Hep3B human HCC cell lines with IC50s of 15.7 and 2.4 μM. VEGFR-2-IN-72 can cause a mild blockage of the cell cycle and induce cell aopoptosis. VEGFR-2-IN-72 can used for the study of hepatocellular carcinoma (HCC) [1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; VEGFR

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(C1=C(OC)C=C2N=CC=C(OC3=CC(C4=CC=CC(C(C)C)=C4)=C(NC(NC5CC5)=O)C=C3)C2=C1)N

Molecular Formula

C30H30N4O4

Molecular Weight

510.58

References & Citations

[1]Sun L, et al. Design, synthesis, and anti-hepatocellular carcinoma activity evaluation of aryl Lenvatinib derivatives: Exploring potential VEGFR-2 inhibitors. Bioorg Chem. 2025 Jul 26;164:108799.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

VEGFR2/KDR/Flk-1

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