CHIPOpt
CHIPOpt, a peptide, is an orthosteric CHIP TPR domain inhibitor with a Kd of ∼16 nM. CHIPOpt has anti-aggregation activity and decreases p.tau ubiquitination with little effect on unmodified tau. CHIPOpt can be used for Alzheimer’s disease research[1].
Product Specifications
UNSPSC
12352209
Target
Tau Protein
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C)N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(O)=O)CC(O)=O)=O)CCC1)=O)CC2=CNC3=CC=CC=C23)=O)CC4=CNC5=CC=CC=C45)=O)CC(C)C
Molecular Formula
C39H47N7O9
Molecular Weight
757.83
References & Citations
[1]Nadel CM, et al. The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT) . J Mol Biol. 2023 Jun 1;435 (11) :168026.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1086374 Inquire
Recombinant Psychromonas ingrahamii Na (+)-translocating NADH-quinone reductase subunit E
Sign In for Pricing
View Details 
