HPK1 ligand-Linker Conjugate 1
HPK1 ligand-Linker Conjugate 1 is a synthesized target protein ligand-linker conjugate that can be used for synthesis of PROTACs, such as PROTAC HPK1 Degrader-5 (HY-175547) . PROTAC HPK1 Degrader-5 is a potent and orally active HPK1 PROTAC degrader with anti-tumor activity[1].
Product Specifications
CAS Number
[3061690-80-7]
UNSPSC
12352005
Target
MAP4K; Target Protein Ligand-Linker Conjugates
Related Pathways
MAPK/ERK Pathway; PROTAC
Field of Research
Cancer
Smiles
O=C(C(CC1)N(C2=O)C(C(C=C3)=C2C=C3N(C4)CC[C@H]4COS(C)(=O)=O)=O)NC1=O
Molecular Formula
C19H21N3O7S
Molecular Weight
435.45
References & Citations
[1]Tong J, et al. Discovery of a Novel Potent and Orally Efficacious PROTAC Degrader of HPK1 for Tumor Immunotherapy. J Med Chem. 2025 Aug 14;68 (15) :15991-16017.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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