HPK1 ligand-Linker Conjugate 1

HPK1 ligand-Linker Conjugate 1 is a synthesized target protein ligand-linker conjugate that can be used for synthesis of PROTACs, such as PROTAC HPK1 Degrader-5 (HY-175547) . PROTAC HPK1 Degrader-5 is a potent and orally active HPK1 PROTAC degrader with anti-tumor activity[1].

Product Specifications

CAS Number

[3061690-80-7]

UNSPSC

12352005

Target

MAP4K; Target Protein Ligand-Linker Conjugates

Related Pathways

MAPK/ERK Pathway; PROTAC

Field of Research

Cancer

Smiles

O=C(C(CC1)N(C2=O)C(C(C=C3)=C2C=C3N(C4)CC[C@H]4COS(C)(=O)=O)=O)NC1=O

Molecular Formula

C19H21N3O7S

Molecular Weight

435.45

References & Citations

[1]Tong J, et al. Discovery of a Novel Potent and Orally Efficacious PROTAC Degrader of HPK1 for Tumor Immunotherapy. J Med Chem. 2025 Aug 14;68 (15) :15991-16017.