HPK1 ligand 4
HPK1 ligand 4 is a PROTAC target protein ligand that can be used for synthesis of PROTACs, such as PROTAC HPK1 Degrader-5. PROTAC HPK1 Degrader-5 is a potent and orally active HPK1 PROTAC degrader with anti-tumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; MAP4K
Related Pathways
MAPK/ERK Pathway; PROTAC
Field of Research
Cancer
Smiles
O=C(N)C1=NC(C2=C(C3=CC=C2)N=CN3C)=C(N=C1NC4=CC=C(C=C4)C5CCN(C(OC(C)(C)C)=O)CC5)NC
Molecular Formula
C30H36N8O3
Molecular Weight
556.66
References & Citations
[1]Tong J, et al. Discovery of a Novel Potent and Orally Efficacious PROTAC Degrader of HPK1 for Tumor Immunotherapy. J Med Chem. 2025 Aug 14;68 (15) :15991-16017.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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