HPK1 ligand 4

HPK1 ligand 4 is a PROTAC target protein ligand that can be used for synthesis of PROTACs, such as PROTAC HPK1 Degrader-5 (HY-175547) . PROTAC HPK1 Degrader-5 is a potent and orally active HPK1 PROTAC degrader with anti-tumor activity[1].

Product Specifications

UNSPSC

12352005

Target

Ligands for Target Protein for PROTAC; MAP4K

Related Pathways

MAPK/ERK Pathway; PROTAC

Field of Research

Cancer

Smiles

O=C(N)C1=NC(C2=C(C3=CC=C2)N=CN3C)=C(N=C1NC4=CC=C(C=C4)C5CCN(C(OC(C)(C)C)=O)CC5)NC

Molecular Formula

C30H36N8O3

Molecular Weight

556.66

References & Citations

[1]Tong J, et al. Discovery of a Novel Potent and Orally Efficacious PROTAC Degrader of HPK1 for Tumor Immunotherapy. J Med Chem. 2025 Aug 14;68 (15) :15991-16017.