Nrf2 activator-21

Nrf2 activator-21 is a Nrf2 activator with dual antioxidant and neuroprotective properties. Nrf2 activator-21 binds to Keap1 Kelch domain and disrupts Keap1-Nrf2 interactions and activate antioxidant defense mechanisms. Nrf2 activator-21 reduces apoptosis and decreases caspase-3 activity in the hippocampal neurons. Nrf2 activator-21 targets cerebral ischemia/reperfusion injury (CIRI) via Nrf2 pathway activation. Nrf2 activator-21 improves neurological function, alleviates anxiety-like behavior, enhances memory in rats with 2-vessel occlusion (2VO) -induced CIRI. Nrf2 activator-21 can be used for the study of cerebral ischemia/reperfusion injury[1].

Product Specifications

CAS Number

[1912404-14-8]

UNSPSC

12352005

Target

Apoptosis; Caspase; Keap1-Nrf2

Related Pathways

Apoptosis; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

COC1=CC=C2C(OC(C(C(/C=C/C3=CC=C(O)C=C3)=O)=C2)=O)=C1

Molecular Formula

C19H14O5

Molecular Weight

322.31

References & Citations

[1]Mohammadnia M, et al. Coumarin-Chalcone derivatives as promising antioxidant agents targeting ischemia/reperfusion injury through Nrf2 pathway activation. Bioorg Chem. 2025 Jul 26;164:108790.