CRBN ligand-Linker Conjugate 1
CRBN ligand-Linker Conjugate 1 is a CRBN ligand-linker conjugate that can be used for synthesis of TQ-3959 (HY-175541) [1].
Product Specifications
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O=C(C(CC1)C2=NOC3=C2C=CC(N4CC(C4)N5CCCCC5)=C3)NC1=O
Molecular Formula
C20H24N4O3
Molecular Weight
368.43
References & Citations
[1]Ren J, et al. Discovery of TQ-3959 as a Potent and Orally Bioavailable BTK PROTAC Degrader Incorporating a Novel Benzisoxazole-Based CRBN Ligand for the Treatment of B-Cell Malignancies. J Med Chem. 2025 Aug 14;68 (15) :15960-15979.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Curated Selection
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