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BTK ligand 16

BTK ligand 16 is a BTK ligand that can be used for synthesis of TQ-3959 (HY-175541) [1].

Product Specifications

UNSPSC

12352005

Target

Btk; Ligands for Target Protein for PROTAC

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

NC(C1=C(NC2=CC=C(C)C=C2)N=C(N3C[C@H](N4CCN(C)C4=O)CCC3)C=N1)=O

Molecular Formula

C21H27N7O2

Molecular Weight

409.48

References & Citations

[1]Ren J, et al. Discovery of TQ-3959 as a Potent and Orally Bioavailable BTK PROTAC Degrader Incorporating a Novel Benzisoxazole-Based CRBN Ligand for the Treatment of B-Cell Malignancies. J Med Chem. 2025 Aug 14;68 (15) :15960-15979.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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