KB-15
KB-15 is a STAT3 inhibitor. KB-15 exhibits potent anti-proliferative activity against AGS gastric cancer cells (IC50 = 0.29 μM) and BGC-823 gastric cancer cells (IC50 = 0.65 μM) . KB-15 exerts anti-tumor effects by inhibiting STAT3 phosphorylation, downregulating HO-1 expression, and promoting intracellular ROS accumulation. KB-15 induces G0/G1 phase cell cycle arrest and apoptosis, as well as suppresses colony formation and migration of gastric cancer cells. KB-15 demonstrates excellent anti-tumor efficacy in BGC-823 subcutaneous xenograft model. KB-15 can be used for the study of gastric cancer[1].
Product Specifications
UNSPSC
12352101
Target
Apoptosis; PARP; Reactive Oxygen Species (ROS) ; STAT
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
ClC1=C(Cl)C=CC(/C=C/C(NNC(/C=C/C2=CC(Cl)=C(Cl)C=C2)=O)=O)=C1
Molecular Formula
C18H12Cl4N2O2
Molecular Weight
430.11
References & Citations
[1]Wu J, et al. Design, synthesis and anti-gastric cancer activity of stable Bisamide curcumin analogues. Bioorg Chem. 2025 Jul 23;164:108793.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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