PDGFRα kinase-IN-2

PDGFRα kinase-IN-2 is a potent PDGFR-α inhibitor with an IC50 of 2.1 nM. PDGFRα kinase-IN-2 exhibits anticancer activity against human colon cancer HT-29 cell with an IC50 of 1.48 μM. PDGFRα kinase-IN-2 has anti-angiogenic activity in zebrafish models and low embryonic lethality. PDGFRα kinase-IN-2 can used for the studies of colon cancer and anti-angiogenesis[1].

Product Specifications

CAS Number

[3066103-58-7]

UNSPSC

12352005

Target

PDGFR

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Cardiovascular Disease

Smiles

COC1=CC2=C(NC3=CC=C(NC(NC4=CC=CC(C)=C4)=O)C=C3)N=CN=C2C=C1OC

Molecular Formula

C24H23N5O3

Molecular Weight

429.47

References & Citations

[1]Wang R, et al. Design, synthesis and biological evaluation of novel platelet-derived growth factor receptor-α (PDGFR-α) inhibitors based on 4-anilinoquinoline and 4-anilinoquinazoline scaffolds. Eur J Med Chem. 2025 Nov 15;298:118015.