USP10-IN-4
USP10-IN-4 is a potent ubiquitin-specific protease 10 (USP10) inhibitor with an IC50 of 10.87 μM and a Kd of 365 nM. USP10-IN-4 effectively inhibits USP10-mediated proteasomal degradation of downstream proteins YAP and p53, leading to the subsequent downregulation of CDK4 in the p53 signaling pathway. USP10-IN-4 promotes apoptosis in HCC cells and inhibits the onset and progression of liver cancer. USP10-IN-4 can used for the study of hepatocellular carcinoma (HCC) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; CDK; Deubiquitinase; MDM-2/p53; YAP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(C(N(CC(NCCC1=CC=C(Cl)C=C1)=O)C2=C3C=CC(C)=C2)=CC3=O)NC4=CC=CC=C4C
Molecular Formula
C28H26ClN3O3
Molecular Weight
487.98
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-175538/
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
CDK4
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