USP10-IN-4

USP10-IN-4 is a potent ubiquitin-specific protease 10 (USP10) inhibitor with an IC50 of 10.87 μM and a Kd of 365 nM. USP10-IN-4 effectively inhibits USP10-mediated proteasomal degradation of downstream proteins YAP and p53, leading to the subsequent downregulation of CDK4 in the p53 signaling pathway. USP10-IN-4 promotes apoptosis in HCC cells and inhibits the onset and progression of liver cancer. USP10-IN-4 can used for the study of hepatocellular carcinoma (HCC) [1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; CDK; Deubiquitinase; MDM-2/p53; YAP

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C(C(N(CC(NCCC1=CC=C(Cl)C=C1)=O)C2=C3C=CC(C)=C2)=CC3=O)NC4=CC=CC=C4C

Molecular Formula

C28H26ClN3O3

Molecular Weight

487.98

References & Citations

[1]Lu Y, et al. Discovery of a ubiquitin-specific protease 10 inhibitor with high binding affinity promoting cell apoptosis via down-regulated CDK4 for the treatment of hepatocellular carcinoma. Bioorg Chem. 2025 Aug;163:108775.