TLR2 antagonist-1
TLR2 antagonist-1 is a selective Toll-like receptor 2 (TLR2) antagonist. TLR2 antagonist-1 can effectively inhibit excessive TLR2 activation (IC50 = 11.41 μM) and the production of inflammatory factors. TLR2 antagonist-1 has metabolic stability with a half-life (T1/2) of 16.67 min in mouse liver microsomes. TLR2 antagonist-1 can be used for the researches of inflammation, immunology, and neurological disease[1].
Product Specifications
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
C/C(C1=CC=C(O)C(O)=C1Cl)=N\OCC2=CC(C3=NOC(C)=N3)=CC(F)=C2
Molecular Formula
C18H15ClFN3O4
Molecular Weight
391.78
References & Citations
[1]Tang X, et al. Discovery of novel TLR2 antagonists as anti-inflammatory agents. Bioorg Chem. 2025 Jul 30;164:108805.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR2
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