M4 mAChR Modulator-2
M4 mAChR Modulator-2 is an orally active, selective, brain-penetrant positive allosteric modulator (PAM) of the M4 muscarinic acetylcholine receptor (M4 mAChR) (EC50 = 513 nM). M4 mAChR Modulator-2 exhibits high target selectivity, showing negligible affinity and low inhibition rates for non-target receptors (D1R/D2R/D3R, 5-HT subtypes, κ/δ/μ opioid receptors, H1, M1/M2) while specifically binding to M4 mAChR with a Ki of 377 nM and an inhibition rate of 62.8%. M4 mAChR Modulator-2 reverses Dizocilpine (MK-801) -induced hyperlocomotion in mice. M4 mAChR Modulator-2 can be used for the study of schizophrenia[1]
Product Specifications
CAS Number
3062458-27-6
UNSPSC
12352005
Target
MAChR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
CC1=C2C(CN(C(CC3CN(C4=CC(C5=CC=C(C#N)C(F)=C5)=NC=C4)C3)=O)C2)=NC(C)=C1
Molecular Formula
C26H24FN5O
Molecular Weight
441.50
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR4
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Monkey Xeroderma Pigmentosum, Complementation Group D ELISA Kit
Monkey Xeroderma Pigmentosum, Complementation Group D ELISA Kit
Monkey Xeroderma Pigmentosum, Complementation Group D ELISA Kit
Monkey Xeroderma Pigmentosum, Complementation Group D ELISA Kit